The scientific research is aimed at studying modern complex organic, inorganic and organic-inorganic biohybrid nanocomplexes developed for pharmacology and various fields of biomedicine.
Subject of research: bacterial and nanocrystalline cellulose; collagen; lipid nanocomplexes; biohybrid polymer complexes based on aerogels and ultralight ultraporous carbon materials; biohybrid nanocomplexes based on biocompatible polymers, biomimetic membranes, "green" nanometals, others.
Research techniques: small-angle X-ray and neutron scattering, X-ray diffraction, scanning electron and atomic force microscopy, optical spectroscopy, dynamic light scattering.
Examples of the research:
Changes in the structure of bacterial cellulose wound dressings that occur during its decomposition caused by enzymes have been studied. The results obtained will help to produce biodegradable dressings with the desired properties for the treatment of burns and other skin injuries (http://www.jinr.ru/posts/nejtronnoe-rasseyanie-pomogaet-sozdat-protivoozhogovye-ranevye-povyazki-s-zadannymi-svojstvami/).
The morphology of new polymers with a branched architecture based on Poly(2-oxazoline), synthesized for the first time at St. Petersburg State University and the stabilization of Ag0 nanoparticles in these polymers have been studied. The lower viscosity and higher stability of this polymer compared to the well-known polyethylene glycol (PEG) make this subject of research very attractive for its use in medicine and pharmacology. Based on the SANS and AFM data, a multilevel structural model of these polymers has been proposed.
Biocompatible nanocomplexes based on natural components: phytogenerated Ag/AgCl nanoparticles, biosimilar membranes and chitosan have been developed to be used in biomedicine. The produced drugs of new generation for targeted drug delivery have shown high efficiency in the fight against resistant microorganisms and also have a high potential in the fight against cancerous tumors (https://scientificrussia.ru/articles/v-oiai-rabotaut-nad-sozdaniem-lekarstv-budusego, http://www1.jinr.ru/News/News_1-2022_sajt.pdf).
Within the framework of the new project "X-ray diffraction analysis for biomedicine", research on biocompatible materials for the development of new generation implants has started.
Cooperation: FLNR JINR, DLNP JINR, Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences (Moscow), National University of Science and Technology MISiS (Moscow), Skolkovo Institute of Science and Technology (Moscow), National Research Centre "Kurchatov Institute" - Federal State Budgetary Scientific Institution Petersburg Nuclear Physics Institute named by B.P. Konstantinov (Gatchina), Institute of Macromolecular Compounds of the Russian Academy of Sciences (St. Petersburg), Federal State Budgetary Scientific Institution “Institute of Experimental Medicine” (St. Petersburg).
Publications:
Rakotoarisoa M., Angelov B., Drechsler M., et al., Liquid crystalline lipid nanoparticles for combined delivery of curcumin, fish oil and BDNF: In vitro neuroprotective potential in a cellular model of tunicamycin-induced endoplasmic reticulum stress. Smart Materials in Medicine, 3, 274-288 (2022). Doi:10.1016/j.smaim.2022.03.001
Smyslov R., Kopitsa G., Gorshkova Y., et al., Novel biocompatible Cu2+-containing composite hydrogels based on bacterial cellulose and poly-1-vinyl-1,2,4-triazole. Smart Materials in Medicine, 3, 382-389 (2022). Doi:10.1016/j.smaim.2022.05.002
Zabrodskaya Y., Egorov V., Sokolov A., et al., Caught red handed: modeling and confirmation of the myeloperoxidase ceruloplasmin alpha-thrombin complex. Biometals, 1-12 (2022). Doi:10.1007/s10534-022-00432-2
Angelova A., Angelov B., Drechsler M., et al., Plasmalogen-based liquid crystalline multiphase structures involving docosapentaenoyl (DPA) derivatives inspired by biological cubic membranes. Frontiers in Cell and Developmental Biology, 9, 617984 (2021). Doi:10.3389/fcell.2021.617984
Gorshkova Y., Barbinta-Patrascu M.E., Bokuchava G., et al., Biological Performances of Plasmonic Biohybrids Based on Phyto-Silver/Silver Chloride. Nanomaterials, 11, 1811 (2021). Doi:10.3390/nano11071811
Barbinta-Patrascu M.E., Gorshkova Y., Ungureanu C., et al., Antitumoral activity of biohybrids based on turmeric and silver/silver chloride nanoparticles. Materials, 14, 4726 (2021). Doi:10.3390/ma14164726
A.D. Yapryntsev, A.E. Baranchikov, A.V. Churakov, G.P. Kopitsa, A.A. Silvestrova, M.V. Golikova, O.S. Ivanova, Yu.E. Gorshkova, V.K. Ivanov. First amorphous and crystalline yttrium lactate: synthesis and structural features. RSC Advances, 11, 30195–30205 (2021). Doi:10.1039/D1RA05923H
Ivanova L.A., Ustinovich K.B., Khamova T.V., et al., Crystal and supramolecular structure of bacterial cellulose hydrolyzed by cellobiohydrolase from Scytalidium candidum 3C: A basis for development of biodegradable wound dressings. Materials, 13, 2087 (2020). Doi:10.3390/ma13092087
Kyzyma O., Bashmakova N., Gorshkova Yu., et al., Interaction between the plant alkaloid berberine and fullerene C70: Experimental and quantum-chemical study, J. Mol. Liq., 278, 452-459 (2019). Doi:10.1016/j.molliq.2019.01.062
Lezov A.A., Gubarev A.S., Podsevalnikova A.N., et al., Temperature-responsive star-shaped poly(2-ethyl-2-oxazoline) and poly(2-isopropyl-2-oxazoline) with central thiacalix[4]arene fragments: structure and properties in solutions. Colloid and Polymer Science, 297, 285 – 296 (2019). Doi:10.1007/s00396-018-4458-9
Lezov A., Gubarev A., Mikhailova M., et al., Star-Shaped Poly(2-ethyl-2-oxazoline) and Poly(2-isopropyl-2-oxazoline) with Central Thiacalix[4]Arene Fragments: Reduction and Stabilization of Silver Nanoparticles. Polymers, 11(12), 2006 (2019). Doi:10.3390/polym11122006